SquaActive™
An Amaranthus-derived squalene standardized to 99% HPLC purity — a plant-based alternative to shark- and olive-derived squalane, serving both cosmetic emollient applications and pharmaceutical adjuvant-precursor applications. Arceli is an India-based manufacturer built around supercritical CO₂ (SCFE) extraction, supplying standardized botanical actives to formulators worldwide.
// Key advantages
// Specification
- Botanical name
- Amaranthus species
- CAS
- 111-02-4
- Standardization
- 99% HPLC Purity
- Dose
- Application-dependent — see technical dossier
- Appearance
- Light yellow
- Solubility
- Soluble in non-polar solvents (oils, hexane, chloroform, ether); insoluble in water
- Shelf life
- 2 years
- Country of origin
- India
- Raw material source
- Edible seeds of Amaranthus
Full certificate of analysis and technical dossier available on request.
// Sourcing & Manufacturing
SquaActive™ is extracted via supercritical CO₂ (SCFE) of Amaranthus species at Arceli's own 300L facility in Dehradun (Selaqui), Uttarakhand — the same GMP, FSSAI, ISO 9001, ISO 22000, and FSSC 22000-certified site that produces every ingredient in the ArcoPure™ line. Available as a standardized branded ingredient for direct purchase, or as the base for private-label and custom-specification manufacturing.
// Mechanism
Isolated and purified from Amaranthus oil to 99% HPLC purity via ArcoPure™, positioned as an Amaranthus-based alternative to MF59-type squalene adjuvant components — a component supplier claim, not a vaccine claim.
Read the compound-level science →// Benefits
- Emollient, anti-aging skin support (cosmetic use)
- Non-comedogenic, clean-beauty positioning
- Vaccine-adjuvant precursor component (pharmaceutical use)
- Drug delivery and wound-care applications
// Key research
Squalene's role as a vaccine-adjuvant component is supported by 5 published reviews and studies on squalene-based (MF59-type) adjuvants below — these describe squalene as a compound class; SquaActive is a component supplier ingredient, not a tested vaccine formulation in its own right.
- 01Brito & Brodin — Current Drug Targets"MF59: a safe and potent vaccine adjuvant" — reviews the mechanism, safety profile and vaccine-response potential of the squalene-based MF59 adjuvant.
- 02Leroux-Roels & Leroux-Roels — VaccineSqualene-based oil-in-water emulsion (MF59) improved antigen-specific T-cell-mediated immune responses in mice.
- 03Singh, Kumar & Gupta — Expert Review of VaccinesAdvances in squalene-based adjuvants and emulsions — efficacy, safety and regulatory considerations for vaccine use.
- 04Del Giudice & Rappuoli — PharmaceuticalsHistorical development, current use and safety/immunogenic properties of squalene as a vaccine adjuvant in humans.
- 05O'Hagan & Wack — Immunology and Cell BiologyRole of squalene in enhancing immunogenicity of pandemic influenza vaccines, including mechanism of action.
Citations refer to published literature on these compounds generally, not to clinical trials of Arceli's specific extract unless otherwise noted. Full dossier available on request.
// Frequently asked
What is SquaActive™ standardized to?
SquaActive™ is standardized to 99% HPLC Purity, verified on every batch using validated analytical methods and powered by Arceli's ArcoPure™ purification platform.
Is SquaActive™ patent-pending?
Yes — SquaActive™ is produced using Arceli's ArcoPure™ technology, covered by a provisional patent application (public record).
What industries use SquaActive™?
SquaActive™ is formulated for Cosmeceuticals, Pharmaceuticals.
What is the typical dose for SquaActive™?
Application-dependent — see technical dossier. Application-specific dosing should be confirmed against the full technical dossier.
What botanical source is SquaActive™ derived from?
SquaActive™ is derived from Amaranthus species (CAS 111-02-4).
What is the shelf life of SquaActive™?
2 years when stored sealed in the original container at room temperature, sheltered from light and moisture.
Is SquaActive™ water-soluble?
Soluble in non-polar solvents (oils, hexane, chloroform, ether); insoluble in water
What does SquaActive™ look like?
Light yellow. Natural batch-to-batch variation in raw material can cause minor color variation without affecting quality or efficacy.
Arceli Lifescience